Human Corneal Epithelial Basement Membrane and Integrin Alterations in Diabetes and Diabetic Retinopathy1
نویسندگان
چکیده
Ophthalmology Research Laboratories, Burns & Allen Research Institute, Cedars-Sinai Medical Center, UCLA Medical School Affiliate, Los Angeles, California (AVL,ZH,GHH,MCK); MGH/Harvard Cutaneous Biology Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts (REB); Department of Animal Physiology, Uppsala University, Uppsala, Sweden (DG); Renal Division, Washington University School of Medicine, St Louis, Missouri (JHM); Okayama University Medical School (YN) and Shigei Medical Research Institute (YS), Okayama, Japan
منابع مشابه
Human corneal epithelial basement membrane and integrin alterations in diabetes and diabetic retinopathy.
Corneas of diabetic patients have abnormal healing and epithelial adhesion, which may be due to alterations of the corneal extracellular matrix (ECM) and basement membrane (BM). To identify such alterations, various ECM and BM components and integrin receptors were studied by immunofluorescence on sections of normal and diabetic human corneas. Age-matched corneas from 15 normal subjects, 10 dia...
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PURPOSE To understand the pathophysiology of the corneal basement membrane in diabetes, we compared the localization of laminin and type IV collagen in the epithelial basement membrane during corneal epithelial wound healing in diabetic and nondiabetic rats. METHODS Streptozotocin was used to induce diabetes in half the rats. Two weeks later, the whole corneal epithelium was debrided. Diabeti...
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PURPOSE We have previously identified specific epithelial proteins with altered expression in human diabetic central corneas. Decreased hepatocyte growth factor receptor (c-met) and increased proteinases were functionally implicated in the changes of these proteins in diabetes. The present study examined whether limbal stem cell marker patterns were altered in diabetic corneas and whether c-met...
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Objective: Alteration in the basement membrane proteins maybe associated with diabetic neuropathy. Fibronectin is one of the most important components of peripheral nerves basement membrane. In this study we investigated the effects of insulin administration on prevention of alteration in fibronectin contents of sciatic nerve in diabetic rats. Materials and Methods: Twenty-four wistar rats wer...
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تاریخ انتشار 2010